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Evocarpine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Evocarpine图片
CAS NO:15266-38-3
包装与价格:
包装价格(元)
5 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
Evocarpine 是从Evodiae fructus分离得到的一种喹诺酮类生物碱,有抗细菌活性。它可通过电压依赖性钙通道抑制 Ca2+内流。

产品描述

Evocarpine shows antimycobacterial, and vasorelaxant effects, it can inhibit Ca2+ influx through voltage-dependent calcium channels.

体外活性

The antimycobacterial and modulating activity of evodiamine (1), rutaecarpine (2) and Evocarpine (3) was tested on mycobacteria including three multidrug-resistant (MDR) clinical isolates of Mycobacterium tuberculosis. Antagonistic effects were concluded from fractional inhibitory concentration (FICI) values. Interaction energies of the compounds were calculated using GLUE docking module implemented in GRID. 1 and 2 exhibited weak inhibition of rapidly growing mycobacteria, however, 1 was active against Myco. tuberculosis H37Rv (MIC = 10 mg l(-1) ) while 2 was inactive. Both 1 and 2 showed a marked antagonistic effect on the susceptibility of different mycobacterial strains to 3 giving FICI values between 5 and 9. The interaction energies between compounds 1 and 2 with compound 3 suggested the possibility of complex formation in solution[1]

Cas No.

15266-38-3

分子式

C23H33NO

分子量

339.51

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years