您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > KH7
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
KH7
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
KH7图片
CAS NO:330676-02-3
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
KH7 是腺苷酸环化酶 (sAC) 特异性的可溶性抑制剂,也是一种 cAMP 抑制剂。它对重组纯化的人类 sACt 蛋白和细胞试验中异源表达的 sACt 的 IC50 为 3 到 10 μM之间。

产品描述

KH7 is a soluble inhibitor of adenylyl cyclase (sAC)-specific. It has IC50s of 3-10 μM toward both recombinant purified human sACt protein and heterologously expressed sACt in cellular assays. KH7 is also a cAMP inhibitor.

体外活性

KH7 prevents the generation of CaSF. KH7 (10 μM) blocks this capacitation-induced cAMP increase. At higher concentrations (50 μM), 5- to 10-fold above its IC50 but still selective for sAC relative to tmACs, KH7 resulted in a significant decrease in the basal cAMP accumulation in sperm regardless of the incubation medium. The myocytes exert a negative inotropic effect (NIE) of approximately 20%, in the presence of KH7. This suggesting that sAC is involved in the normal generation of basal cardiac contractility [1,2].

Cas No.

330676-02-3

分子式

C17H15BrN4O2S

分子量

419.3

储存和溶解度

H2O:< 0.1 mg/mL (insoluble)
DMSO:100 mg/mL (238.49 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years