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Kartogenin(KGN)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Kartogenin(KGN)图片
CAS NO:4727-31-5
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)317.34
FormulaC20H15NO3
CAS No.4727-31-5
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 63 mg/mL (198.5 mM)
Water: <1 mg/mL
Ethanol: 18 mg/mL (56.7 mM)
Solubility (In vivo) O=C(O)C1=CC=CC=C1C(NC2=CC=C(C3=CC=CC=C3)C=C2)=O
Synonyms KGN
实验参考方法
In Vitro

In vitro activity: Kartogenin induces chondrocyte differentiation from hMSCs by enhancing the nuclear localization of CBFβ, and protects articular chondrocytes. Kartogenin promotes the type-I collagen synthesis of dermal fibroblasts via activation of the smad4/smad5 pathway without obvious cytotoxicity on fibroblasts’ viability, morphology and survival.


Cell Assay: For the cell viability assay, fibroblasts are seeded on six-well plates, followed by Kartogenin or DMSO treatment. According to the manufacturer’s instructions, cell viability and viability are assessed by AlamarBlue assay.

In VivoKartogenin promotes cartilage repair in collagenase VII (10 μM)– and surgery (100 μM)-induced OA models in mice. Kartogenin (100 nM) also stimulats collagen synthesis in the mouse dermis. In addition, Kartogenin stimulates mouse limb skeletal growth and synovial joint development.
Animal modelCollagenase VII-induced OA mouse model and Surgery-induced OA mouse model
Formulation & DosageDissolved in saline; 10 μM or 100 μM; Intra-articular injection
References

Biochem Biophys Res Commun. 2014 Jul 18;450(1):568-74; Science. 2012 May 11;336(6082):717-21.