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Cetrorelix Acetate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cetrorelix Acetate图片
CAS NO:145672-81-7
包装与价格:
包装价格(元)
1 mg电议
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Cetrorelix
醋酸西曲瑞克
产品介绍
CetRORelix 是一种GnRH受体的强效拮抗剂(IC50:1.21 nM)。

产品描述

Cetrorelix Acetate is gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM.

体外活性

GnRH-I antagonist Cetrorelix inhibited growth of ES-2 cell line only at 1000 ng/ml.?The incubation of ES-2 ovarian cancer cells in vitro with an GnRH-I antibody inhibited cell proliferation in a time and concentration-dependent manner.?GnRH-I may function as an autocrine growth factor in this ovarian cancer cell line [1].

体内活性

Cetrorelix inhibits the activation of hGnRHR and a downstream luciferase reporter gene in murine LTK- cells by the GnRHR agonist [D-Trp6]GnRH (IC50 = 1.2 nM). In vivo, cetrorelix (60 μg per day) reduces tumor volume to 35% of control and decreases serum luteinizing hormone levels by 50% in a human epithelial ovarian cancer mouse xenograft model[2].

Cas No.

145672-81-7

分子式

C72H96ClN17O16

分子量

1491.11

别名

Cetrorelix;醋酸西曲瑞克

储存和溶解度

DMSO:50 mg/mL (33.53 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years