Leachianone A 是从槐花中分离的一种天然产物，可诱导细胞凋亡，具有抗疟疾、抗炎和细胞毒性作用。

Leachianone A is a potential antitoxic agent, it shows inhibitory effects on cadmium- Induced cytotoxicity.

In this study, Leachianone A, isolated from Radix Sophorae, possessed a profound cytotoxic activity against human hepatoma cell line HepG2 in vitro, with an IC(50) value of 3.4microg/ml post-48-h treatment. Its action mechanism via induction of apoptosis involved both extrinsic and intrinsic pathways. Its anti-tumor effect was further demonstrated in vivo by 17-54% reduction of tumor size in HepG2-bearing nude mice, in which no toxicity to the heart and liver tissues was observed[1]

Intravenous injection of 20 mg/kg and 30 mg/kg Leachianone A once daily for 30 days significantly reduced tumor volume in LA-treated nude mice by 17-54% compared to nude mice given vehicle alone[1].

97938-31-3

C26H30O6

438.51

里查酮 A;Isokurarinone

DMSO:75 mg/ml (171.03 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years