MCHR1 antagonist 2 是有效的黑色素聚集激素受体 1 拮抗剂,IC50为 65 nM。它也抑制HERG,在IMR-32 细胞中的IC50为 4.0 nM。
产品描述
MCHR1 antagonist 2 is an antagonist of melanin-concentratin hormone receptor 1(MCH1-R, IC50 = 65 nM) and also inhibits hERG.
体外活性
MCHR1 antagonist 2 has inhibitory effects on Ca2+?flux, and hERG, with IC50s of 196?±?30 nM and 4.0?±?0.8 nM, respectively, in IMR-32 cells.MCHR1 antagonist 2 is an antagonist of melanin concentrating hormone receptor 1, with an IC50 of 65 nM.
Cas No.
863115-70-2
分子式
C23H21FN2O5
分子量
424.42
储存和溶解度
DMSO:9 mg/mL (21.21 mM),ultrasonic and adjust pH to 6 with HCl
Powder: -20°C for 3 years
In solvent: -80°C for 2 years