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(S)-IDO1-IN-5
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(S)-IDO1-IN-5图片
CAS NO:2166616-76-6
包装与价格:
包装价格(元)
Free Sample (0.1-0.5mg)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品介绍
(S)-IDO1-IN-5 是 IDO1-IN-5 的 S 型同分异构体。IDO1-IN-5 是一种有效、选择性、可透过血脑屏障的 IDO1 抑制剂,能够与缺乏血红素的 apo-IDO1 结合,但无法与结合有成熟血红素的 IDO1 结合。
Cas No.2166616-76-6
Canonical SMILESO=C(N[C@H](C1=CC2=C(N(C(C3CCOCC3)=O)CC2)C=C1)C)C4=CC=C(F)C=C4
分子式C23H25FN2O3
分子量396.45
溶解度DMSO: 300 mg/mL (756.72 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

(S)-IDO1-IN-5 is the S-isomer of IDO1-IN-5. IDO1-IN-5 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1[1].

[1]. Frank C. Dorsey, et al. Abstract 5245: Identification and characterization of the IDO1 inhibitor LY3381916. Cancer Research. 2018, 78(13).