BC-1215 是一种 F-box protein 3 抑制剂。它能够稳定 TRaf1-TRaf6 来抑制 Fbxo3-TRaf 激活途径。它与 ApaG 相互作用，阻碍来自人 PBMC 广谱 TH1 细胞因子的分泌。

BC-1215 is an inhibitor of F-box protein 3 (FBXO3, a ubiquitin E3 ligase component, IC50=0.9 μg/mL for IL-1β release).

A small molecule inhibitor BC-1215 argeting Fbxo3 was sufficient to lessen severity of cytokine-driven inflammation in several murine disease models.

Tested effects of administration of BC-1215 in a model of a cecal ligation and puncture (CLP)-induced sepsis. Mice with CLP had significantly increased cytokine release compared to sham treated mice. BC-1215 treatment significantly attenuated CLP-induced secretion of all three circulating pro-inflammatory cytokines in mice . BC-1215 also decreased bacterial counts in the CLP model and modestly produced inhibition of bacterial growth using Kirby Bauer testing

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