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ML347
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ML347图片
CAS NO:1062368-49-3
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)352.39
FormulaC22H16N4O
CAS No.1062368-49-3
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 10 mg/mL (28.4 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
SMILESCOC1=CC=C(C(C=N2)=CN3C2=C(C4=CC=CC5=C4C=CC=N5)C=N3)C=C1
SynonymsLDN-193719; LDN193719; LDN 193719; ML-347; ML347; ML 347
实验参考方法
In Vitro

In vitro activity: ML347 also shows potency in BMP-responsive C2C12BRA cells with IC50 of 15 nM, and designated an MLPCN probe. ML347 displays high plasma protein binding in human, rat and mouse plasma.


Kinase Assay: ML347(DN193719) is a highly selective ALK1/ALK2 inhibitor with IC50s of 46/32 nM; shows>300-fold selectivity for ALK2 vs. ALK3. IC50 value: Target: ALK1/ALK2 ML347 has IC50’s of 46 and 32 nM, respectively, against ALK1 and ALK2; however, the IC50 against ALK3 is 10,800 nM,>300-fold selective over ALK3. ML347 is completely inactive against all the other kinases tested (with weak activity against ALK6, 9830 nM and KDR (VEGFR2)19,700 nM). ML347 is potent in the BMP4 cell assay (152 nM).


Cell Assay: ML347 also shows effective inhibition with IC50 value of 152nM in the BMP4 cell based assay using C2C12BRA cells.

In Vivo
Animal model
Formulation & Dosage
ReferencesBioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52