Sulfo-SMCC sodium 是一种异双功能、不可裂解的 ADC 交联剂，带有 N-羟基琥珀酰亚胺酯和马来酰亚胺基团，分别与伯胺和巯基反应。

Sulfo-SMCC sodium is a commonly used hetero-bifunctional, non-cleavable ADC crosslinker bearing N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively.

The crosslinker Sulfo-SMCC is composed of a maleimide and an N-hydroxysuccinimide ester group to bind to sulfhydryl groups and primary amines, respectively. Sulfo-SMCC inhibits the end-to-end annealing of stabilized Microtubules (MTs). MTs are treated with 250 μM Sulfo-SMCC, and imaged after incubation for 0 h, 6 h, and 24 h. MTs treated with Sulfo-SMCC exhibit a constant mean length, independent of the incubation time[1].

92921-24-9

C16H18N2NaO9S

437.38

H2O:12 mg/mL (27.50 mM),Need ultrasonic
DMSO:125 mg/mL (286.45 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years