TD-106 is a modulator of cereblon (CRBN), and can be used for targeted protein degradation. BRD4 PROTACs with TD-106 induce BRD4 degradation.

TD-106 inhibits the proliferation of NCI-H929 myeloma cell line with an CC50?of?0.039?μM, and induces the degradation of IKZF1/3 in NCI-H929?cells.

In SCID mice with TMD-8 xenograft model, TD-106 possesses anti-myeloma activity .

2250288-69-6

C12H11N5O3

273.25

DMSO:125 mg/mL (457.46 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years