d-Epigalbacin是一种天然木质素。d-Epigalbacin是一种强效、选择性的JNKs抑制剂,JNK1、JNK2和JNK3的IC50s分别为1.7μM、2.9μM和1.74μM。
产品描述
d-Epigalbacin is a naturally occurring lignin. d-Epigalbacin is a potent, selective JNKs inhibitor, with IC50s of 1.7 μM, 2.9 μM and 1.74 μM for JNK1, JNK2 and JNK3, respectively.
体外活性
(–)-zuonin A binds the D-recruitment site of JNK. (–)-zuonin A inhibits the activation and phosphorylation of JNK by MKK4 and MKK7[1].
Cas No.
84709-25-1
分子式
C20H20O5
分子量
340.37
别名
(-)-Zuonin A;表加巴辛
储存和溶解度
DMSO:90 mg/mL (264.4 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years