DRI-C21045 是一种有效的 CD40-CD40L 协同刺激蛋白-蛋白质相互作用的选择性抑制剂，IC50 为 0.17 μM。它显示对 CD40L 诱导的 NF-Κb 活化和 B 细胞增殖的浓度依赖性抑制，IC50分别为 17.1 μM 和 4.5 μM。

Dri-c21045 showed concentration-dependent inhibition of NF-kB activation and all CD40L induced by B cell proliferation with IC50 of 17.1 μM and 4.5 μM, respectively. Dri-c21045 is an effective selective inhibitor of CD40-CD40L synergistic stimulator protein-protein interaction (PPI) with IC50 of 0.17 μM.

2101765-81-3

C32H24N2O7S

580.61

DMSO:2 mg/mL (3.44 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years