PaloNOSetron hydrochloride 是一种 5-HT3 拮抗剂，用于预防和治疗化疗引起的恶心和呕吐。

Palonosetron is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.

Palonosetron血浆半衰期比同种类拮抗剂长,约为40 小时 (ondansetron,4小时; tropisetron,7.3 小时; dolasetron,7.5 小时; ranisetron,8.9小时)。Palonosetron对5-HT3受体的结合亲和性比其它5-HT3受体拮抗剂高100倍,pKi为10.5(granisetron pKi 8.91,tropisetron pKi8.81,ondansetron pK i8.39,dolasetron pK i 7.6)。

135729-62-3

C19H25ClN2O

332.87

Palonosetron HCl;RS 25259;盐酸帕洛诺司琼;RS 25259 197

H2O:100 mg/mL (300.42 mM),Need ultrasonic
DMSO:3.33 mg/mL (10.00 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years