Mesaconine 是来自 Aconitum carmichaelii Debx 的一种成分。Mesaconine 具有心脏作用和抗 NF-Κb 活性。 Mesaconine可能是麻黄附子细辛汤抗炎和免疫抑制的部分物质基础。

Mesaconine is an ingredient from Aconitum carmichaelii Debx.. Mesaconine has a cardiac effect and anti-NF-κB activity. Mesaconine may be part of the material basis of Mahuang Fuzi Xixin decoction on anti-inflammation and immune suppression.

The anti-inflammatory effect of SFI was verified in vitro with endothelial cells. After detecting the cell viability, the expression of interleukin-6 (IL-6), inhibitor of nuclear factor kappa-B kinase (IKK), phosphorylated IKK, phosphorylated NF-κB and phosphorylated IκB-α± from the supernatant were determined. SFI could significantly suppress inflammatory responses, and the mechanism may be via an NF-κB-dependent pathway. Mesaconine is the first reported SFI compounds to have NF-κB inhibitor activity[1].

6792-09-2

C24H39NO9

485.574

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years