CAIX Inhibitor S4 是一种有效的碳酸酐酶 IX/XII 抑制剂，Ki 分别为 7 nM 和 2 nM。 CA II 和 CA I 的 Ki 分别为 546 和 5600 nM。

CAIX Inhibitor S4 is an effective inhibitor of carbonic anhydrase IX/XII with a Ki of 7 nM and 2 nM, respectively. The Kis for CA II and CA I are 546 and 5600 nM.

CAIX Inhibitor S4 (33 μM; 15-60 min) delays the cell spreading of MDA-MB-231 cells in anoxia but essentially not in normoxia. CAIX Inhibitor S4 (1, 10, 100 μM; 24 h) inhibits the proliferation of MDA-MB-231, HCT116 and HT29 cells in a dose-dependent manner with IC50s of 481 μM, >1000 μM, and 20 μM, respectively. CAIX Inhibitor S4 (3.3-33 μM; 24 h) inhibits the eGFP-MDA-MB-231 cell migration in anoxia in a concentration-dependent manner[1].

CAIX Inhibitor S4 (10 mg/kg; i.p.) inhibits the number of lung metastasis in orthotopic MDA-MB-231 mouse model without affecting primary tumor growth[1].

1330061-67-0

C15H17N3O4S

335.38

S4

DMSO:245 mg/mL (730.51 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years