CYNARIN 是一种咖啡酰奎宁酸衍生物，具有抗氧化、自由基清除作用。

CYNARIN is a natural product. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.

CYNARIN have neuroprotective effects.CYNARIN prevents Aβ(42)-induced neurotoxicity through the activation of PI3K/Akt followed by the stimulation of Trk A, then the inhibition of GSK3β as well as the modulation of Bcl-2/Bax.

The neuroprotective effects of 1,5-DQA against amyloid β(1-42) (Aβ(42))-induced neurotoxicity in primary neuronal culture. To evaluate the neuroprotective effects of 1,5-DQA, primary cultured cortical neurons from neonate rats were pretreated with 1,5-DQA for 2 hours and then treated with 40 μmol/L Aβ(42) for 6 hours. Cell counting kit-8, Hoechst staining and Western blotting were used for detecting the protective mechanism. Comparisons between two groups were evaluated by independent t test, and multiple comparisons were analyzed by one-way analysis of variance (ANOVA).

19870-46-3

C25H24O12

516.45

1,3-O-Dicaffeoylquinic acid;CYNARIN;1,3-二咖啡酰奎宁酸;1,5-Dicaffeoylquinic acid;Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1S,3R,4R,5R)-

DMSO:23 mg/mL (44.53 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years