ROSlin 2 bromide 是一种 p53 再激活剂,可破坏 FAK 和 p53 的结合。 ROSlin 2 bromide 具有抗癌作用。
产品描述
Roslin 2 bromide is a p53 reactivator that disrupts the binding of FAK and p5Roslin 2 bromide exhibits anticancer effects.
体外活性
Roslin 2 bromide decreases cancer cell viability and clonogenicity in a p53-dependent manner[1].
体内活性
Roslin 2 bromide (60 mg/kg; i.p) significantly decreased tumor growth, disrupts the complex of FAK and p53, and up-regulated p21 in HCT116 p53+/+ but not in HCT116 p53-/- xenografts[1].
Cas No.
29574-21-8
分子式
C13H19BrN4
分子量
311.22
别名
Roslin2;Roslin-2
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years