Podocarpusflavone A is a DNA topoisomerase I inhibitor. It has moderated anti-proliferative activity induce cell apoptosis in MCF-7.

Podocarpusflavone A shows significant inhibitions against KB, DLD, HEp-2, MCF-7 tumor cell lines (ED50 4.56-16.24 μg/mL) and induces cell apoptosis in MCF-7 via mainly sub-G1/S phase arrest. PF (40 ug/mL, 24 hr) significantly induced about 10 folds of cell deaths and growth arrest in S-phase than the control group.

22136-74-9

C31H20O10

552.48

DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years