Bisabolangelone 是从没药中分离出来的一种倍半萜衍生物，具有抗炎作用。它通过阻断巨噬细胞内的NF-kappaB和MAPK通路抑制脂多糖刺激的炎症，具有抗溃疡作用。

Bisabolangelone has anti-tumor, anti-inflammatory, anti-microbial, and antioxidant activities, it inhibits dendritic cell functions by blocking MAPK and NF-κB signaling.

Bisabolangelone (BISA), isolated from the roots of Angelica koreana, has many pharmacological activities, such as anti-tumor, anti-microbial, antioxidant, and anti-inflammatory activities. BISA attenuated the production of pro-inflammatory cytokines including interleukin (IL)-12, IL-1β, and tumor necrosis factor-alpha (TNF-α), migration to macrophage inflammatory protein-3 beta, and allo-T cell activating ability of DCs. In addition, BISA affected endocytosis of DCs. Molecular studies showed that BISA suppressed MAPK phosphorylation and nuclear translocation of NF-κB p50/p65. BISA inhibited DC functions by blocking MAPK and NF-κB signaling[2].

30557-81-4

C15H20O3

248.32

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years