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Ginkgolide J
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ginkgolide J图片
CAS NO:107438-79-9
包装与价格:
包装价格(元)
20 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
7-beta-Hydroxyginkgolide A
BN 52024
银杏内酯 J
银杏内酯J
产品介绍
Ginkgolide J 是一种银杏叶中非黄酮部分的主要成分(IC50:12-54 μM),具有神经保护和抗神经元凋亡功能。

产品描述

Ginkgolide J has neuroprotective activity, it can prevent A beta(1-42) induced inhibition of long-term potentiation in the CA1 region of mouse hippocampal slices.

体外活性

A new Ginkgo biloba extract P8A (TTL), 70% enriched with terpene trilactones, prevents A beta induced inhibition of long-term potentiation in the CA1 region of mouse hippocampal slices. This neuroprotective effect is attributed in large part to Ginkgolide J that completely replicates the effect of the extract. Ginkgolide J is also capable of inhibiting cell death of rodent hippocampal neurons caused by A beta[1].

细胞实验

Hippocampal cultures were treated by adding 10 μM Aβ1-42 in its oligomeric form with or without P8A, or alternatively with and without each of the individual ginkgolides and bilobalide (GA, GB, GC GJ, BB).??these compounds were dissolved in DMSO and added to the culture medium at a ratio of 1:1000 (v/v), yielding a 0.1% DMSO solution.?After 24 hrs the number of viable cells was assessed by nuclear counting.?In a separate set of experiments, viable cells were counted by using the ethidium homodimer/calcein-AM combination of vital dyes (LIVE/DEAD Viability/Cytotoxicity Kit for mammalian cells;?Invitrogen), according to the manufacturer instructions.?Values represent the mean SEM of three consecutive experiments.?Each experiment was performed in triplicate[1].

Cas No.

107438-79-9

分子式

C20H24O10

分子量

424.402

别名

7-beta-Hydroxyginkgolide A;BN 52024;银杏内酯 J;银杏内酯J

储存和溶解度

DMSO:60 mg/ml (141.38 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years