CAS NO: | 1597440-03-3 |
包装: | 50mg, 100mg, 250mg |
规格: | ≥98% |
(Rac)-BRD0705 is a less active racemate of BRD0705. BRD0705 is a highly potent, paralog specific and orally bioavailable GSK3α inhibitor with an IC50 of 66 nM and a Kd of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML). References: [1]. Wagner FF, et al. Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med. 2018 Mar 7;10(431). pii: eaam8460.
[2]. Edward Scolnick, et al. Uses of paralog-selective inhibitors of gsk3 kinases. US20160375006A1.
纯度:≥98%
CAS:1597440-03-3