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Myricitrin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Myricitrin图片
CAS NO:17912-87-7
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)464.38
FormulaC21H20O12
CAS No.17912-87-7
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 93 mg/mL (200.3 mM)
Water: <1 mg/mL
Ethanol: 1 mg/mL (2.1 mM)
Other info

Chemical Name: 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one

InChi Key: DCYOADKBABEMIQ-OWMUPTOHSA-N

InChi Code: InChI=1S/C21H20O12/c1-6-14(26)17(29)18(30)21(31-6)33-20-16(28)13-9(23)4-8(22)5-12(13)32-19(20)7-2-10(24)15(27)11(25)3-7/h2-6,14,17-18,21-27,29-30H,1H3/t6-,14-,17+,18+,21-/m0/s1

SMILES Code: O=C1C(O[C@H]2[C@@H]([C@@H]([C@H]([C@H](C)O2)O)O)O)=C(C3=CC(O)=C(O)C(O)=C3)OC4=CC(O)=CC(O)=C14

SynonymsMyricitrine; Myricetrin; Myricitroside
实验参考方法
In Vitro

In vitro activity: Myricitrin, a flavonoid compound isolated from the root bark of Myrica cerifera, which exerts antinociceptive effect. Myricitrin produces pronounced antinociception against chemical and mechanical models of pain in rodents via preventing the protein kinase C (PKC) alpha and PKC epsilon activation by phorbol myristate acetate (PMA). Another study proves that opening of voltage- and small-conductance calcium-gated K(+) channels and reduction of calcium influx leads to the antinociceptive of myricitrin. Myricitrin also decreases H2O2-induced apoptosis in vascular endothelial cells via inhibition of p53 gene expression, activation of caspase-3 and the MAPK signaling pathway, and alteration of the patterns of pro-apoptotic and anti-apoptotic gene expression.

In VivoIn mice, myricitrin (i.p. 10 mg/kg or 30 mg/kg) blocks apomorphine-induced stereotypy and climbing, and increases hindlimb retraction time (HRT).
Animal modelMale adult Swiss albino mice
Formulation & DosageDissolved in Tween 80 followed by saline; 10, 30 mg/kg; i.p. injection
References

J Pharmacol Exp Ther. 2006 Feb;316(2):789-96; Eur J Pharmacol. 2007 Jul 19;567(3):198-205; Prog Neuropsychopharmacol Biol Psychiatry. 2011 Aug 15;35(7):1636-44.