SenNOSide B 是在番泻叶的叶子和豆荚中大量发现的蒽醌苷。它可通过与 PDGF-BB 及其受体结合并下调 PDGFR-β 信号传导途径来抑制 PDGF 刺激的细胞增殖。

Sennoside B is an anthranoid. Anthranoid derivatives are used all over the world as a treatment for constipation.

Sennoside B, a kind of irritant laxative isolated from rhei rhizome, inhibits platelet-derived growth factor (PDGF)-stimulated MG63 cell proliferation by binding to PDGF-BB and its receptor and down-regulating the PDGFR-beta signaling pathway. Pre-incubation of PDGF-BB with sennoside B inhibits the phosphorylation of pathway components including Ak strain transforming protein (AKT), signal transducer and activator of transcription 5 (STAT-5) and extracellular signal-regulated kinase 1/2 (ERK1/2). [2] It also inhibits bovine serum monoamine oxidase with IC50 of 9 μM. [1]

LD50: Mice 5000 mg/kg (i.g.); Rats 5000 mg/kg (i.g.). [3]

128-57-4

C42H38O20

862.746

番泻苷 B;番泻苷B

H2O:Insoluble
DMSO:91 mg/mL(105.5 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years