Ombuin 是一种从花椒中分离出的广谱抗菌剂，MIC 为 125 至 500 μg/mL。

Ombuin has anti-inflammatory activity, it inhibits some macrophage functions involved in the inflammatory process.

Compounds 1-7 were evaluated as inhibitors of some macrophage functions involved in the inflammatory process. These seven compounds significantly and dose-dependently inhibited lipopolysaccharide (LPS) and interferon (IFN)-gamma induced nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12]. The concentration causing a 50% inhibition (IC50) of NO, TNF-alpha and IL-12 production by compounds 1, 2 and 7 was approximately 30, 50 and 10 microM, respectively, while at 50, 200 and 40 microM compounds 3, 4, and 5, 6 showed 15-30% inhibition, respectively. On the other hand, compounds 3 and 7 showed no inhibitory effect, while compounds 1, 4-6 reduced by around 10-30% the synthesis of NO by macrophages, when inducible NO synthase was already expressed with LPS/IFN-gamma for 24 h[1]

529-40-8

C17H14O7

330.29

商陆黄素;商陆素

DMSO:60 mg/ml (181.66 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years