Flavokawain B 是从卡瓦醉椒的根提取物中，分离出的查尔酮。它是一种凋亡诱导剂，可抑制各种癌细胞株生长。它以极低的无毒浓度抑制人脑内皮细胞的迁移和血管形成，具有抗血管生成活性。

1. Flavokawain B has potent anti-inflammatory activity, can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. 2. Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathways. 3. Flavokawain B induces apoptosis, has the potential usefulness of FKB for prevention and treatment of hormone-refractory prostate cancer in an adjuvant setting. 4. Flavokawain B acts through ROS generation and GADD153 up-regulation to regulate the expression of Bcl-2 family members, thereby inducing mitochondrial dysfunction and apoptosis in HCT116 cells.

1775-97-9

C17H16O4

284.311

2'-Hydroxy-4',6'-Dimethoxychalcone;黄卡瓦胡椒素B;Flavokawin B;Flavokavain B

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.:Soluble
DMSO:38 mg/mL(133.7 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years