2-Methoxycinnamaldehyde 是一种肉桂中的天然产物。它能通过使线粒体膜电位 (ΔΨm) 损失 、激活 Caspase-3 和 Caspase-9，来抑制细胞增殖和诱导细胞凋亡，具有抗肿瘤活性。它还能抑制血小板衍生生长因子诱导的 HASMC 迁移。

2-Methoxycinnamaldehyde (2-MCA) is a natural compound of Cinnamomum cassia,has been widely studied with regard to its antitumor activity.

2-methoxycinnamaldehyde(2-MCA) inhibited cell proliferation in SK-Hep-1 cells in a dose- and time-dependent manner. The inhibitory concentration (IC50) value following 48 hours of incubation was 25.72 μM[1].

Cells were seeded in 96-well culture plates (1×10^4 cells/well). After incubated for 24 hours, the cells were treated with different concentrations of 2-MCA for 24 hours, 48 hours, and 72 hours. The cell viability was determined by Cell Proliferation Kit II (XTT) following the manufacturer's protocol. The absorbance was measured using Tecan infinite M200 spectrophotometer at 492 nm with a reference wavelength of 650 nm[1].

1504-74-1

C10H10O2

162.188

2'-甲氧基肉桂醛;O-methoxycinnamaldehyde

DMSO:32mg/mL(197.3mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years