Oxypeucedanin 是呋喃香豆素衍生物，分离自Angelica dahurica。它是选择性开放通道阻滞剂，可抑制hKv1.5通道电流，IC50值为 76 nM。它延长心脏动作电位持续时间，是潜在的抗心律失常试剂。它通过抑制癌细胞迁移来诱导细胞凋亡。

1. Oxypeucedanin has novel anticancer effect, mediated via induction of G2-M cell cycle arrest and apoptosis in human prostate carcinoma DU145 cells. 2. Oxypeucedanin is a kind of open-channel blocker of the hKv1.5 channel and it prolongs the APD; therefore, it is an excellent candidate as an antiarrhythmic drug for atrial fibrillation.

737-52-0

C16H14O5

286.283

氧化前胡素;Oxypeucadanin;(+-)-Oxypeucedanin

DMSO:83.8 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years