7-Xylosyl-10-deacetyltaxol 是一种紫杉醇衍生物，具有改进的药理特性和更高的水溶性，用于治疗癌症。

7-Xylosyl-10-deacetyltaxol paclitaxel is a Paclitaxel derivative with improved pharmacological features and higher water solubility,used in Chinese clinics to treat cancer.

7-Xylosyl-10-deacetyltaxol induced mitotic cell cycle arrest and apoptosis as measured by flow cytometry, DNA laddering, and transmission electron microscopy. Pro-apoptotic Bax and Bad protein expression was up-regulated and anti-apoptotic Bcl-2 and Bcl-XL expression down-regulated, which lead to a disturbance of the mitochondrial membrane permeability and to the activation of caspase-9[1].

7-Xylosyl-10-deacetyltaxol is an active compound used in traditional Chinese medicine to treat cancer.7-Xylosyl-10-deacetyltaxol through the intestinal epithelium is partially counteracted by the action of an outwardly directed efflux pump, presumably P-glycoprotein. The relatively high apparent permeability coefficient ( P(app)) for the apical to basolateral 7-Xylosyl-10-deacetyltaxol transport (16.3?±?6.3?×?10 (-6)?cm/s; n?=?3) suggests that the drug may still be effectively absorbed in the intestinal tract[2].

90332-63-1

C50H57NO17

943.996

10-Deacetyltaxol 7-Xyloside;7-Xylosyl-10-deacetyltaxol;10-Deacetylpaclitaxel 7-Xyloside;7-木糖甙-10-脱乙酰基紫杉醇;10-Deacetyl-7-xylosyltaxol

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