Avicularin 是存在多种植物中有生物活性的黄酮类化合物，具有抗过敏、抗炎、保肝、抗氧化、抗肿瘤等功能。它能通过调节 NF-Κb(p65)、COX-2 和 PPAR-γ 的活性来改善人类肝细胞癌。在 LPS 刺激的 RAW 264.7 巨噬细胞中，它通过抑制 ERK 信号通路产生抗炎活性。

1. Avicularin exhibits anti-inflammatory activity through the suppression of ERK signaling pathway in LPS-stimulated RAW 264.7 macrophage cells. 2. Avicularin inhibits the accumulation of the intracellular lipids by decreasing C/EBPα-activated GLUT4-mediated glucose uptake in adipocytes and potently inhibiting fatty acid synthase.

572-30-5

C20H18O11

434.35

Fenicularin;扁蓄苷

H2O:1.15 mg/mL
DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years