Pristimerin是一种可逆的单酰基甘油脂肪酶高效抑制剂，IC50值为93 nM。

1. Pristimerin has anticancer activity , treatment with Pristimerin may be a potential strategy for the suppression of hypoxia-induced metastasis through the reversal of hypoxia-induced stem cell characteristics and EMT in cancer cells. 2. Pristimerin down-regulates the expression of pro-inflammatory mediators through blocking of NF-κB activation by inhibiting interconnected ROS/IKK/NF-κB signaling pathways, can effectively inhibit both arthritic inflammation and cartilage and bone damage in the joints.

1258-84-0

C30H40O4

464.646

扁塑藤素;Celastrol methyl ester

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years