Primin 是存在于Primula obconica叶和茎毛状体中的天然产物，显示出抗菌和抗癌活性。

Primin is a natural product stored in trichomes on leaves and stems of Primula obconica, with antimycobacterial, and strong antineoplastic actions.

Primin showed very potent activity against Trypanosoma brucei rhodesiense (IC50 0.144 microM) and Leishmania donovani (IC50 0.711 microM), and revealed low cytotoxicity (IC50 15.4 microM) on mammalian cells. Only moderate inhibitory activity was observed against Mycobacterium tuberculosis, Trypanosoma cruzi, and Plasmodium falciparum. When tested for in vivo efficacy in a Trypanosoma b. brucei rodent model, Primin failed to cure the infection at 20 mg/kg given intraperitoneally. Primin was too toxic in vivo at a higher concentration (30 mg/kg, injected i.p. route) in mice infected with L. donovani.

15121-94-5

C12H16O3

208.25

DMSO:60 mg/ml (288.12 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years