Dehydroevodiamine hydrochloride 是分离自吴茱萸叶中，能够抑制 AChE。 它能够调节一氧化氮的产生，具有降压和神经保护作用。

Dehydroevodiamine (DHE), a natural compound isolated from Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production.

Dehydroevodiaminehydrochloride has strong protective effects against cognitive impairments through its antioxidant activity and inhibition of neurotoxicity and intracellular calcium. Thus, DHED may be an important therapeutic agent for memory-impaired symptoms.

The effects of dehydroevodiamine·HCl (DHED) on cognitive improvement and the related mechanism in memory-impaired rat models, namely, a scopolamine-induced amnesia model and a Aβ1-42-infused model. The cognitive effects of DHED were measured using a water maze test and a passive avoidance test in the memory-impaired rat models. The results demonstrate that DHED (10 mg/kg, p.o.) and Donepezil (1 mg/kg, p.o.) ameliorated the spatial memory impairment in the scopolamine-induced amnestic rats.

111664-82-5

C19H16ClN3O

337.81

DMSO:37 mg/mL (109.53 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years