3,5,6,7,8,3',4'-Heptemthoxyflavone 是来自蜜柑皮中的黄酮，具有抗肿瘤起始活性和抗神经炎症作用。它能通过 cAMP/ERK/CREB 信号诱导脑源性神经营养因子表达，降低 C6 细胞磷酸二酯酶活性。它能抑制胶原酶的活性，增加人真皮成纤维细胞新生细胞中 I 型前胶原含量。

3,3',4',5,6,7,8-Heptamethoxyflavone(HMF) has neuroprotective, chemopreventive, anti-allergic, anti-inflammatory, immunomodulatory, anti-aging and photoprotective effects; it inhibits collagenase activity and induces type I procollagen synthesis in HDFn cells, and against nitric oxide (NO) carcinogenesis.

3,5,6,7,8,3',4'-heptamethoxyflavone (HMF), from C. unshiu peels using ethanol extraction and hexane fractionation.?HMF inhibited collagenase activity and increased type I procollagen content in UV-induced human dermal fibroblast neonatal (HDFn) cells.?HMF also suppressed the expression of matrix metalloproteinases 1 (MMP-1) and induced the expression of type I procollagen protein in UV-induced HDFn cells.?Additionally, HMF inhibited ultraviolet B (UVB)-induced phosphorylation of the mitogen-activated protein kinases (MAPK) cascade signaling components-ERK, JNK, and c-Jun-which are involved in the induction of MMP-1 expression.?Furthermore, HMF affected the TGF-β/Smad signaling pathway, which is involved in the regulation of type I procollagen expression.?In particular, HMF induced Smad3 protein expression and suppressed Smad7 protein expression in UV-induced HDFn cells in a dose-dependent manner.

1178-24-1

C22H24O9

432.42

3,3',4',5,6,7,8-heptamethoxyflavone;3,5,6,7,8,3',4'-七甲氧基黄酮

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years