Sanggenon C 是一种从桑属的根皮中分离得到的黄烷酮 Diels-Alder 加合物化合物。它可抑制NF-Κb活性，抑制 RAW264.7 细胞中诱导型一氧化氮合酶的表达，以及肿瘤坏死因子-α 刺激的细胞粘附和血管细胞粘附分子-1 的表达。 它具有抗氧化和抗炎作用，也有抑制胰脂肪酶作用。

1. Sanggenone C inhibits tumor cellular proteasomal activity and cell viability, via induction of cell cycle arrest and cell death , inhibiting the proteasome function. 2. Sanggenone C and O inhibited NO production and iNOS expression by suppressing NF-κB activity and IκBα activation; inhibited TNF-alpha -stimulated PMN-HSC adhesion and expression of VCAM-1 by suppressing the activation of NF-kappaB.

80651-76-9

C40H36O12

708.716

桑根酮C;桑根酮 C;Sanggenone C

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years