BI-9321 triHCl is a highly potent, specific and cellular active nuclear receptor-binding SET domain 3 (NSD3)-PWWP1 domain antagonist with a Kd value of 166 nM. BI-9321 triHCl is inactive against NSD2-PWWP1 and NSD3-PWWP2. BI-9321 triHCl specifically disrupts histone interactions of the NSD3-PWWP1 domain with an IC50 of 1.2 μM in U2OS cells. References: [1]. Bottcher J, et al. Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3. Nat Chem Biol. 2019 Aug;15(8):822-829.

纯度：≥98%

CAS：2387510-87-2