ONO-8711 是一种有效且选择性的EP1 受体竞争性拮抗剂(对人和小鼠 EP1 的Ki分别为 0.6 和 1.7 nM)。ONO-8711 在结肠癌、乳腺癌和口腔癌小鼠模型中的有效降低肿瘤发生率和多样性。

ONO-8711 is a potent and selective competitive antagonist of EP1 receptor with Kis of 0.6 nM and 1.7 nM for human and mouse EP1, respectively. ONO-8711 effectively reduces tumor incidence and multiplicity in mouse models of colon, breast, and oral cancer [1].

216158-34-8

C22H30ClNO4S

440

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years