Lodoxamide tromethamine 是一种的肥大细胞稳定剂，具有抗过敏特性，可用于治疗哮喘和过敏性结膜炎的研究。

Lodoxamide tromethamine is a mast cell stabilizer with anti-allergic properties and can be used in studies about the treatment of asthma and allergic conjunctivitis.

In purified rat peritoneal mast cells, Lodoxamide tromethamine inhibits ionophore-induced 45Ca influx with associated histamine release[1]. Lodoxamide tromethamine significantly and dose-dependently inhibits the chemotactic response of eosinophils to fMLP and to IL-5. Lodoxamide tromethamine strongly inhibits the release of eosinophil peroxidase after IgA-dependent activation and inhibits the release of eosinophil cationic protein and eosinophil-derived neurotoxin to a lesser extent[4].

In Ascaris-sensitized anesthetized rhesus monkeys, Lodoxamide tromethamine significantly inhibits the increased respiratory frequency and decreased tidal volume induced by antigen challenge[1]. The addition of Lodoxamide tromethamine to Euro-Collins or University of Wisconsin solution increases oxygenation, decreases microvascular permeability, and increases compliance thereby decreasing lung reperfusion injury[2].

63610-09-3

C19H28ClN5O12

553.91

DMSO:15 mg/mL (27.1 mM),Need ultrasonic and warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years