mTOR inhibitor-1是一种新型 ATP 竞争性 mTOR 抑制剂，可抑制细胞生长和增殖，诱导自噬。

C-4 is a potential ATP-competitive inhibitor of mTOR. C-4 could inhibit cell growth and proliferation.

The addition of C-4 (mTOR inhibitor-1, 0~12.8 μg/ml) directly decreases the level of activated mTOR (p-mTORser2448) which is phosphorylated at Ser2448. The proliferation of A549 cells is strongly inhibited by C-4, and the inhibitory effect is time- and dose314 dependent. The IC50 of C-4 at 24 h is calculated as 3.176 μM.

468747-17-3

C16H15BrN2O3

363.21

DMSO:70 mg/mL (192.72 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years