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Luxeptinib
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Luxeptinib图片
CAS NO:1616428-23-9
包装与价格:
包装价格(元)
25 mg电议
50 mg电议

产品介绍

产品描述

Luxeptinib (CG-806) is an orally active, reversible, first-in-class, non-covalent and potent pan-FLT3/pan-BTK inhibitor. Luxeptinib induces cell cycle arrest, apoptosis or autophagy in acute myeloid leukemia cells[1][2][3][4].

体外活性

Luxeptinib (MEC-1 CLL cells; 0.1~10 μM; 72 hours) inhibits cells proliferation with an IC50 of 32 nM[1].Luxeptinib inhibits BCR signaling-induced phosphorylation of BTK, PLCg2, AKT, ERK1/2, S6 ribosomal protein and strongly suppresses SYK phosphorylation in primary chronic lymphocytic leukemia (CLL) cells[1]. Luxeptinib (MV4-11 cells; 500 pM; 1 hour) completely inhibits phosphorylation of FLT3 and STAT5[2].

Cas No.

1616428-23-9

分子式

C25H17F4N5O2

分子量

495.438

储存和溶解度

DMSO:125 mg/mL (252.31 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years