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Rebeccamycin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Rebeccamycin图片
CAS NO:93908-02-2
包装:5 mg
市场价:7000元

产品介绍

产品描述

Rebeccamycin is an antitumor antibiotic+ inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I. It also has a negligible effect on protein kinase C and topoisomerase II.

体外活性

Rebeccamycin produced by the actinomycete Saccharotrix aerocolonigenes. It has activity against several human tumor cell lines, including lung adenocarcinoma, colon carcinoma, and nasopharyngeal carcinoma. Rebeccamycin displays antibacterial activity against several Gram-positive bacteria, including Staphylococcus aureus and Streptococcus faecalis [1][3].

体内活性

Rebeccamycin (2-256 mg/kg; i.p.; daily for 9 days) prolongs survival in B16 melanoma and L1210 leukemia[2].

Cas No.

93908-02-2

分子式

C27H21Cl2N3O7

分子量

570.38

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years