您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > CC-115
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
CC-115
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CC-115图片
CAS NO:1228013-15-7
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
CC 115
产品介绍
CC-115 是一种双重 mTOR/DNA-PK 的抑制剂,IC50分别为 21 nM 和 13 nM,可阻断mTORC1和mTORC2信号通路。

产品描述

CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).

体外活性

The IC50 values for CC-115 are >10 μM against a panel of CYP enzymes and >33 μM for the hERG ion channel. When screened in a single point assay at 10 μM against a Cerep receptor and enzyme panel only one target was inhibited >50% (PDE3, IC50 = 0.63 μM).

体内活性

CC-115 shows good PK profiles across multiple species with 53%, 76%, and 100% oral bioavailability in mouse, rat, and dog, respectively. CC-115, with favorable physicochemical and pharmacokinetic properties, demonstrates mTOR pathway inhibition and tumor growth inhibition, as well as a good safety profile, suitable for Clinicalal development.

细胞实验

Freshly isolated CLL cells are treated with different concentrations of CC-115 for 30 minutes. Subsequently, the cells are exposed to 5-Gy γ-radiation or treated with 10 µg/mL bleomycin (EMD Millipore, Billerica, MA) and incubated for 30 minutes, and cell lysates are made. (Only for Reference)

Cas No.

1228013-15-7

分子式

C16H16N8O

分子量

336.359

别名

CC 115

储存和溶解度

DMSO:62 mg/mL (184.3 mM)
H2O:<1 mgml
Ethanol:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years