SIS17 是一种有效的选择性 HDAC 11 抑制剂，IC50 值为 0.83 μM。它可抑制 HDAC11 底物丝氨酸羟甲基转移酶 2 的去肉豆蔻酰化。

SIS17 is a potent and selective HDAC 11 inhibitor with an IC50 value of 0.83 μM. SIS17, is active in cells and inhibited the demyristoylation of a known HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs.

SIS17, is active in cells and inhibited the demyristoylation of a known HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs.

2374313-54-7

C21H38N2OS

366.61

DMSO:125 mg/mL (340.97 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years