AZD-9574 是 SSB 位点的 PARP1 特异性抑制剂。 AZD-9574 具有抗癌活性，可用于 HRD+ 乳腺癌和晚期实体恶性肿瘤的研究。

AZD-9574 is a selective inhibitor of PARP1 at the sites of SSBs. AZD-9574 exhibits anti-cancer activities and can be used in studies about HRD+ breast cancer and advanced solid malignancies.

AZD-9574 inhibits PARP1 with IC50s range between 0.3-2 nM in all tested cell lines which is >8000-fold selectivity compared to PARP2, PARP3, PARP5a and PARP6[1].

In an intracranial xenograft mice model of breast cancer brain metastases, AZD-9574 (3 mg/kg) shows sustained tumour growth suppression and results in a significantly extended survival of mice[1].

2756333-39-6

C21H22F2N6O2

428.44

DMSO:8 mg/mL (18.67 mM),ultrasonic and warming and heat to 60°C
DMSO:20 mg/mL (46.68mM),ultrasonic and adjust pH to 4 with HCl
Powder: -20°C for 3 years
In solvent: -80°C for 2 years