Niraparib R-enantiomer 是一种PARP1抑制剂，IC50为 2.4 nM。

Niraparib R-enantiomer is an inhibitor of PARP1(IC50 of 2.4 nM).

Niraparib R-enantiomer has somewhat lower in vitro metabolic clearance than the Niraparib S-enantiomer in rat liver microsomes, but Niraparib S-enantiomer is more potent in cell based assays (PARylation EC50, Niraparib R-enantiomer=30 nM, Niraparib S-enantiomer=4.0 nM; BRCA1-HeLa CC50, Niraparib R-enantiomer=470, Niraparib S-enantiomer=34 nM). [1].

1038915-58-0

C19H20N4O

320.39

Niraparib R-enantiomer;MK 4827 (R-enantiomer)

DMSO:30 mg/mL (93.63 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years