2'-Deoxy-2'-fluorocytidine 是一种核苷类似物，可有效抑制刚果出血热病毒的复制。2'-Deoxy-2'-fluorocytidine与 T705 的协同作用会增强对CCHFV 复制的抵抗效力。

2'-Deoxy-2'-fluorocytidine is an nucleoside analog and inhibits of Crimean-Congo hemorrhagic fever virus (CCHFV) replication potently.

2'-Deoxy-2'-fluorocytidine (EC50 = 61 ± 18 nM) has 200 × the potency of ribavirin (EC50 = 12.5 ± 2.6 μM), as well as 17 × the potency of T-705 (favipiravir), another compound with reported anti-CCHFV activity (EC50 = 1.03 ± 0.16 μM). 2'-Deoxy-2'-fluorocytidine acts synergistically with T-705 to inhibit CCHFV replication without causing cytotoxicity[1].

10212-20-1

C9H12FN3O4

245.21

H2O:5 mg/mL (20.39 mM),ultrasonic and warming and heat to 60°C
Powder: -20°C for 3 years
In solvent: -80°C for 2 years