LY518674 是一种高效、选择性的PPARα拮抗剂,对人PPARα 作用的EC50值为 42 nM。它能降低甘油三酸酯,增加 HDL-C,可用于研究动脉粥样硬化。
产品描述
LY518674 decreases triglycerides and increases HDL-C and is used for the treatment of atherosclerosis. LY518674 is an effective and selective PPARα antagonist (EC50: 42 nM for human PPARα).
体内活性
LY518674 decreases triglycerides and increased HDL-C in vivo[2]. LY518674 significantly enhances apolipoprotein A-I (apoA-I) turnover without a major impact on steady-state levels of apoA-I or high-density lipoprotein-cholesterol (HDL-C) [3].
Cas No.
425671-29-0
分子式
C23H27N3O4
分子量
409.48
别名
LY-674
储存和溶解度
DMSO:250 mg/mL (610.53 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years