SC-236 是一种具有口服活性的COX-2特异性抑制剂和PPARγ激动剂。它可通过 c-Jun 氨基端抑制激活蛋白-1活性，在小鼠模型中通过抑制 ERK 的磷酸化发挥抗炎作用。

Sc 236 is an orally active and selective inhibitor of COX-2 (IC50 of 0.005 μM and 17.8 μM for COX-2 and COX-1, respectively).

SC-236 protects against cartilage damage in addition to reducing inflammation and pain for those with osteoarthritis

170569-86-5

C16H11ClF3N3O2S

401.78

4-(5-(4-氯苯基)-3-(三氟甲基)-1H-;Sc 236

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years