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RP 70676
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
RP 70676图片
CAS NO:136609-26-2
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
RP 70676 是ACAT抑制剂,抑制大鼠和兔子中 ACAT的IC50分别为 25 和 44 nM。

产品描述

RP 70676 is a potent ACAT inhibitor(rat and rabbit ACAT with IC50 of 25 and 44 nM ).

体外活性

RP 70676 is a potent rabbit arterial ACAT inhibitor with IC50 of 40 nM and has been shown to be an effective inhibitor of ACAT derived from a number of tissues and species including man. The IC50 values range from 21 nM for hamster liver ACAT to 108 nM for enzyme from the intestine of cholesterol fed rabbits; in human hepatic tissues(IC50 : 44 nM). Murine macrophages the compound has an IC50 of 540 nM in whole cell P388D.

体内活性

In NZW rabbits,RP 70676 (10 mg/kg, p.o.) is well absorbed with plasma levels.

Cas No.

136609-26-2

分子式

C25H28N4S

分子量

416.58

储存和溶解度

DMSO:125 mg/mL (300.06 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years