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Nitrosoglutathione
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nitrosoglutathione图片
CAS NO:57564-91-7
包装:5 mg
市场价:569元

产品名称
S-亚硝基谷胱甘肽
SNOG
S-Nitrosoglutathione
Glutathione thionitrite
GSNO
产品介绍
GSNO 是一种外源性的 NO 供体,是大鼠酒精脱氢酶III类同工酶的底物,能够减少脑血管紧张素II依赖性及非依赖型的 AT1 受体反应。

产品描述

GSNO is an endogenous transnitrosation donor involved in S-nitrosation of a variety of cellular proteins. GSNO, an exogenous NO donor and substrate of rat alcohol dehydrogenase class III isoenzyme, inhibits cerebral angiotensin II-dependent and -independent AT1 receptor responses.

体外活性

GSNO completely abolished the AngII-dependent AT1 receptor-mediated vasoconstriction of cerebral arteries. GSNO had no impact on responses to other vasoconstrictors sharing (phenylephrine, U46619) or not (5-HT) the same signalling pathway[1].

体内活性

Elevated blood pressure, proteinuria, and intrauterine growth restriction associated with PE were induced in Sprague-Dawley rats using L-NAME. These were partially reversed with the use of GSNO[3].

Cas No.

57564-91-7

分子式

C10H16N4O7S

分子量

336.31

别名

S-亚硝基谷胱甘肽;SNOG;S-Nitrosoglutathione;Glutathione thionitrite;GSNO

储存和溶解度

DMSO:Soluble
H2O:20 mg/ml(59.47 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years